{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boedhoe PS"],"funding":["NIBIB NIH HHS","Swiss National Science Foundation","NCATS NIH HHS","NIMH NIH HHS","Dutch Research Council (NWO)","Wellcome Trust"],"pagination":["60-69"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5344782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["174(1)"],"pubmed_abstract":["<h4>Objective</h4>Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide.<h4>Method</h4>T<sub>1</sub> images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a m"],"journal":["The American journal of psychiatry"],"pubmed_title":["Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis."],"pmcid":["PMC5344782"],"funding_grant_id":["320030","R21 MH093889","917-15-318","130237","U54 EB020403","UL1 TR001863","R01 MH085321","R01 MH101493"],"pubmed_authors":["Lochner C","Minuzzi L","Alonso P","Bose A","Koch K","Hibar DP","Soriano-Mas C","van der Werf YD","Arnold PD","Beucke JC","Stevens MC","Ameis SH","Fouche JP","Huyser C","Kaufmann C","Hanna GL","Wang Z","van Wingen GA","Sato JR","Bargallo N","Simpson HB","van den Heuvel OA","Calvo R","Fontaine M","Xu J","Batistuzzo MC","Hu H","Tolin DF","Cath DC","Miguel EC","Calvo A","de Vries FE","Thompson PM","Mataix-Cols D","Xu X","Abe Y","de Wit SJ","Spalletta G","Gimenez M","Piras F","Marsh R","Ikari K","Menchon JS","Martinez-Zalacain I","Huyser Ch","Kaufmann Ch","Kwon JS","Szeszko PR","Cheng Y","Menchon JM","Narayanaswamy JC","Busatto GF","Khadka S","Hoexter MQ","Liu Y","Boedhoe PS","Bollettini I","Venkatasubramanian G","Fitzgerald KD","Zhao Q","Benedetti F","Brem S","Gruner P","Simpson","Kathmann N","Morer A","Denys D","Dallaspezia S","Jahanshad N","Veltman DJ","Nakamae T","Nakao T","Wang Zh","Fang Y","Schmaal L","Pittenger C","Lazaro L","Reddy","Cho KI","Stein DJ","Minuzzii L","Pittenger Ch","Reddy YC","Soreni N","ENIGMA OCD Working Group","Walitza S","Lochner Ch","Yun JY","Gimenez"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.","description":"<h4>Objective</h4>Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide.<h4>Method</h4>T<sub>1</sub> images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a m","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-04-19T08:28:40.793Z","creation":"2019-03-27T02:38:19Z"},"accession":"S-EPMC5344782","cross_references":{"pubmed":["27609241"],"doi":["10.1176/appi.ajp.2016.16020201"]}}