{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["176(2)"],"submitter":["Kobylewski SE"],"funding":["Renumeration for teaching","UC Toxic Substance and Training Grant"],"pubmed_abstract":["Fruits, nuts, legumes, and vegetables are rich sources of boron (B), an essential plant nutrient with chemopreventive properties. Blood boric acid (BA) levels reflect recent B intake, and men at the US mean intake have a reported non-fasting level of 10 μM. Treatment of DU-145 prostate cancer cells with physiological concentrations of BA inhibits cell proliferation without causing apoptosis and activates eukaryotic initiation factor 2 (eIF2α). EIF2α induces cell differentiation and protects cells by redirecting gene expression to manage endoplasmic reticulum stress. Our objective was to determine the temporal expression of endoplasmic reticulum (ER) stress-activated genes in DU-145 prostate cells treated with 10 μM BA. Immunoblots showed post-treatment increases in eIF2α protein at 30 min "],"journal":["Biological trace element research"],"pagination":["278-293"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5344959"],"repository":["biostudies-literature"],"pubmed_title":["Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake."],"pmcid":["PMC5344959"],"pubmed_authors":["Henderson KA","Yamada KE","Eckhert CD","Kobylewski SE"],"additional_accession":[]},"is_claimable":false,"name":"Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.","description":"Fruits, nuts, legumes, and vegetables are rich sources of boron (B), an essential plant nutrient with chemopreventive properties. Blood boric acid (BA) levels reflect recent B intake, and men at the US mean intake have a reported non-fasting level of 10 μM. Treatment of DU-145 prostate cancer cells with physiological concentrations of BA inhibits cell proliferation without causing apoptosis and activates eukaryotic initiation factor 2 (eIF2α). EIF2α induces cell differentiation and protects cells by redirecting gene expression to manage endoplasmic reticulum stress. Our objective was to determine the temporal expression of endoplasmic reticulum (ER) stress-activated genes in DU-145 prostate cells treated with 10 μM BA. Immunoblots showed post-treatment increases in eIF2α protein at 30 min ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2026-05-30T03:39:29.346Z","creation":"2019-03-27T02:38:20Z"},"accession":"S-EPMC5344959","cross_references":{"pubmed":["27587023"],"doi":["10.1007/s12011-016-0824-y"]}}