biostudies-literatureDriessen JHVersus ArthritisMedical Research CouncilNational Institute for Health Research (NIHR)923-926https://www.ebi.ac.uk/biostudies/studies/S-EPMC5346876biostudies-literatureUnknown83(4)The aim of the present study was to estimate the effect of incretins on fracture risk in the real-world situation by meta-analysis of the available population-based cohort data. Pubmed and Embase were searched for original articles investigating use of incretin agents, and fracture risk up to December 2015. Adjusted results were extracted and pooled by use of generic inverse variance methods, assuming a random-effects model. Neither current dipeptidyl peptidase 4-inhibitor use nor current glucagon-like peptide 1 receptor agonist use was associated with a decreased risk of fracture: pooled relative risk (pooled RR [95% confidence interval]: 1.02 [0.91-1.13] and 1.03 [0.87-1.22]), respectively. This meta-analysis demonstrated that current use of incretin agents, was not associated with decreBritish journal of clinical pharmacologyThe use of incretins and fractures - a meta-analysis on population-based real life data.PMC5346876NF-SI-0508-10082MC_U147585819MC_UP_A620_1014G0400491U1475000001MC_U147585824NF-SI-0513-10085MC_UU_12011/121231MC_U147585827HTA/10/33/0417702Neef Cvan den Bergh JPVestergaard PDriessen JHvan Onzenoort HHarvey NCHenry RMde Vries FfalseThe use of incretins and fractures - a meta-analysis on population-based real life data.The aim of the present study was to estimate the effect of incretins on fracture risk in the real-world situation by meta-analysis of the available population-based cohort data. Pubmed and Embase were searched for original articles investigating use of incretin agents, and fracture risk up to December 2015. Adjusted results were extracted and pooled by use of generic inverse variance methods, assuming a random-effects model. Neither current dipeptidyl peptidase 4-inhibitor use nor current glucagon-like peptide 1 receptor agonist use was associated with a decreased risk of fracture: pooled relative risk (pooled RR [95% confidence interval]: 1.02 [0.91-1.13] and 1.03 [0.87-1.22]), respectively. This meta-analysis demonstrated that current use of incretin agents, was not associated with decre2017-01-01T00:00:00Z2017 Apr2025-06-01T02:40:01.423Z2025-06-01T02:40:01.423ZS-EPMC53468762778028810.1111/bcp.13167