{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rimfeld K"],"funding":["Economic and Social Research Council","HHS | National Institutes of Health","NICHD NIH HHS","European Research Council","Medical Research Council"],"pagination":["2777-2782"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5347574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(10)"],"pubmed_abstract":["Spatial abilities encompass several skills differentiable from general cognitive ability (<i>g</i>). Importantly, spatial abilities have been shown to be significant predictors of many life outcomes, even after controlling for <i>g.</i> To date, no studies have analyzed the genetic architecture of diverse spatial abilities using a multivariate approach. We developed \"gamified\" measures of diverse putative spatial abilities. The battery of 10 tests was administered online to 1,367 twin pairs (age 19-21) from the UK-representative Twins Early Development Study (TEDS). We show that spatial abilities constitute a single factor, both phenotypically and genetically, even after controlling for <i>g</i> This spatial ability factor is highly heritable (69%). We draw three conclusions: (<i>i</i>) The high heritability of spatial ability makes it a good target for gene-hunting research; (<i>ii</i>) some genes will be specific to spatial ability, independent of <i>g</i>; and (<i>iii</i>) these genes will be associated with all components of spatial ability."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Phenotypic and genetic evidence for a unifactorial structure of spatial abilities."],"pmcid":["PMC5347574"],"funding_grant_id":["R01 HD044454","R01 HD059215","HD044454","1667469","1427589","1241769","295366","G0500079","G0901245","G19/2","MR/M021475/1","1365137"],"pubmed_authors":["Dale PS","Kovas Y","Rodic M","Rimfeld K","Selzam S","Schofield K","Malanchini M","Plomin R","Shakeshaft NG"],"additional_accession":[]},"is_claimable":false,"name":"Phenotypic and genetic evidence for a unifactorial structure of spatial abilities.","description":"Spatial abilities encompass several skills differentiable from general cognitive ability (<i>g</i>). Importantly, spatial abilities have been shown to be significant predictors of many life outcomes, even after controlling for <i>g.</i> To date, no studies have analyzed the genetic architecture of diverse spatial abilities using a multivariate approach. We developed \"gamified\" measures of diverse putative spatial abilities. The battery of 10 tests was administered online to 1,367 twin pairs (age 19-21) from the UK-representative Twins Early Development Study (TEDS). We show that spatial abilities constitute a single factor, both phenotypically and genetically, even after controlling for <i>g</i> This spatial ability factor is highly heritable (69%). We draw three conclusions: (<i>i</i>) The high heritability of spatial ability makes it a good target for gene-hunting research; (<i>ii</i>) some genes will be specific to spatial ability, independent of <i>g</i>; and (<i>iii</i>) these genes will be associated with all components of spatial ability.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2026-05-05T07:22:50.712Z","creation":"2019-03-27T02:38:29Z"},"accession":"S-EPMC5347574","cross_references":{"pubmed":["28223478"],"doi":["10.1073/pnas.1607883114"]}}