{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(52)"],"submitter":["Wang R"],"pubmed_abstract":["Cancer stem cells (CSCs) are a key target for reducing tumor growth, metastasis, and recurrence. Redox status is a critical factor in the maintenance of CSCs, and the antioxidant enzyme Peroxiredoxin 2 (Prdx2) plays an important role in the development of colon cancer. Therefore, we investigated the contribution of Prdx2 to the maintenance of stemness of colon CSCs. Here, we used short-hairpin RNAs and a Prdx2-overexpression vector to determine the effects of Prdx2. We demonstrated that knockdown of Prdx2 reduced the self-renewal and sphere formation and resulted in increased 5-FU-induced apoptosis in human colon CSCs. Prdx2 overexpression induced reversion of the self-renewal and sphere formation. Furthermore, the effects of Prdx2 resulted in an altered expression of stemness associated w"],"journal":["Oncotarget"],"pagination":["86816-86828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5349956"],"repository":["biostudies-literature"],"pubmed_title":["Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer."],"pmcid":["PMC5349956"],"pubmed_authors":["Lv Z","Liu M","Fu Z","Zhang S","You W","Xu J","Xiong Y","Guo J","Wang R","Wei J","Du K","Peng L","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.","description":"Cancer stem cells (CSCs) are a key target for reducing tumor growth, metastasis, and recurrence. Redox status is a critical factor in the maintenance of CSCs, and the antioxidant enzyme Peroxiredoxin 2 (Prdx2) plays an important role in the development of colon cancer. Therefore, we investigated the contribution of Prdx2 to the maintenance of stemness of colon CSCs. Here, we used short-hairpin RNAs and a Prdx2-overexpression vector to determine the effects of Prdx2. We demonstrated that knockdown of Prdx2 reduced the self-renewal and sphere formation and resulted in increased 5-FU-induced apoptosis in human colon CSCs. Prdx2 overexpression induced reversion of the self-renewal and sphere formation. Furthermore, the effects of Prdx2 resulted in an altered expression of stemness associated w","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-04-26T19:21:12.283Z","creation":"2020-11-07T11:32:23Z"},"accession":"S-EPMC5349956","cross_references":{"pubmed":["27894099"],"doi":["10.18632/oncotarget.13559"]}}