{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(52)"],"submitter":["McKenzie C"],"pubmed_abstract":["Effective therapeutics exploit common characteristics shared amongst cancers. As many cancers present chromosomal instability (CIN), one possible approach to treat these cancers could be to increase their CIN above a threshold that would affect their viability. Here, we investigated whether causing polyploidy by cytokinesis failure could represent a useful approach. We show that cytokinesis failure caused by depletion of Citron kinase (CIT-K) dramatically decreased cell proliferation in breast, cervical and colorectal cancer cells. CIT-K depletion activated the Hippo tumor suppressor pathway in normal, but not in cancer cells, indicating that cancer cells have evolved mechanisms to bypass this control. CIT-K depleted cancer cells died via apoptosis in a caspase 7 dependent manner and, cons"],"journal":["Oncotarget"],"pagination":["87323-87341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5349991"],"repository":["biostudies-literature"],"pubmed_title":["Investigating cytokinesis failure as a strategy in cancer therapy."],"pmcid":["PMC5349991"],"pubmed_authors":["McKenzie C","D'Avino PP"],"additional_accession":[]},"is_claimable":false,"name":"Investigating cytokinesis failure as a strategy in cancer therapy.","description":"Effective therapeutics exploit common characteristics shared amongst cancers. As many cancers present chromosomal instability (CIN), one possible approach to treat these cancers could be to increase their CIN above a threshold that would affect their viability. Here, we investigated whether causing polyploidy by cytokinesis failure could represent a useful approach. We show that cytokinesis failure caused by depletion of Citron kinase (CIT-K) dramatically decreased cell proliferation in breast, cervical and colorectal cancer cells. CIT-K depletion activated the Hippo tumor suppressor pathway in normal, but not in cancer cells, indicating that cancer cells have evolved mechanisms to bypass this control. CIT-K depleted cancer cells died via apoptosis in a caspase 7 dependent manner and, cons","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-04-26T01:06:50.089Z","creation":"2019-03-27T02:38:38Z"},"accession":"S-EPMC5349991","cross_references":{"pubmed":["27895316"],"doi":["10.18632/oncotarget.13556"]}}