{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Powell DA"],"funding":["National Institutes of Health"],"pagination":["206"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5350118"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Natural resistance-associated macrophage protein (NRAMP) encoded by the <i>Slc11a1</i> gene is a membrane-associated transporter of divalent metal ions. Murine <i>Slc11a1</i> has two known alleles, a functional <i>Slc11a1</i><sup>Gly169</sup>, which is found in DBA2/J, NOD/LtJ, and 129p3/J and related mouse strains, and a non-functional <i>Slc11a1</i><sup>Asp169</sup>, that is found in C56Bl/6J (B6) and BALB/cJ mice. B6 mice congenic for <i>Slc11a1</i><sup>Gly169</sup> (B6-<i>Slc11a1<sup>G169</sup></i> ) are markedly resistant to the intracellular pathogens <i>Salmonella, Leishmania</i>, and <i>Mycobacterium tuberculosis</i>. We examined the host cell response and replication of <i>Francisella</i> in B6-<i>Slc11a1<sup>G169</sup></i> mice. Bone marrow-derived macrophages from either B6-<i>S"],"journal":["Frontiers in immunology"],"pubmed_title":["Efficacy of Resistance to <i>Francisella</i> Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection."],"pmcid":["PMC5350118"],"funding_grant_id":["U54 AIO57157-06"],"pubmed_authors":["Powell DA","Frelinger JA"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of Resistance to <i>Francisella</i> Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.","description":"Natural resistance-associated macrophage protein (NRAMP) encoded by the <i>Slc11a1</i> gene is a membrane-associated transporter of divalent metal ions. Murine <i>Slc11a1</i> has two known alleles, a functional <i>Slc11a1</i><sup>Gly169</sup>, which is found in DBA2/J, NOD/LtJ, and 129p3/J and related mouse strains, and a non-functional <i>Slc11a1</i><sup>Asp169</sup>, that is found in C56Bl/6J (B6) and BALB/cJ mice. B6 mice congenic for <i>Slc11a1</i><sup>Gly169</sup> (B6-<i>Slc11a1<sup>G169</sup></i> ) are markedly resistant to the intracellular pathogens <i>Salmonella, Leishmania</i>, and <i>Mycobacterium tuberculosis</i>. We examined the host cell response and replication of <i>Francisella</i> in B6-<i>Slc11a1<sup>G169</sup></i> mice. Bone marrow-derived macrophages from either B6-<i>S","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-04T09:00:24.63Z","creation":"2019-03-27T02:38:38Z"},"accession":"S-EPMC5350118","cross_references":{"pubmed":["28360906"],"doi":["10.3389/fimmu.2017.00206"]}}