biostudies-literaturePowell DANational Institutes of Health206https://www.ebi.ac.uk/biostudies/studies/S-EPMC5350118biostudies-literatureUnknown8Natural resistance-associated macrophage protein (NRAMP) encoded by the <i>Slc11a1</i> gene is a membrane-associated transporter of divalent metal ions. Murine <i>Slc11a1</i> has two known alleles, a functional <i>Slc11a1</i>^Gly169, which is found in DBA2/J, NOD/LtJ, and 129p3/J and related mouse strains, and a non-functional <i>Slc11a1</i>^Asp169, that is found in C56Bl/6J (B6) and BALB/cJ mice. B6 mice congenic for <i>Slc11a1</i>^Gly169 (B6-<i>Slc11a1^G169</i> ) are markedly resistant to the intracellular pathogens <i>Salmonella, Leishmania</i>, and <i>Mycobacterium tuberculosis</i>. We examined the host cell response and replication of <i>Francisella</i> in B6-<i>Slc11a1^G169</i> mice. Bone marrow-derived macrophages from either B6-<i>SFrontiers in immunologyEfficacy of Resistance to <i>Francisella</i> Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.PMC5350118U54 AIO57157-06Powell DAFrelinger JAfalseEfficacy of Resistance to <i>Francisella</i> Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.Natural resistance-associated macrophage protein (NRAMP) encoded by the <i>Slc11a1</i> gene is a membrane-associated transporter of divalent metal ions. Murine <i>Slc11a1</i> has two known alleles, a functional <i>Slc11a1</i>^Gly169, which is found in DBA2/J, NOD/LtJ, and 129p3/J and related mouse strains, and a non-functional <i>Slc11a1</i>^Asp169, that is found in C56Bl/6J (B6) and BALB/cJ mice. B6 mice congenic for <i>Slc11a1</i>^Gly169 (B6-<i>Slc11a1^G169</i> ) are markedly resistant to the intracellular pathogens <i>Salmonella, Leishmania</i>, and <i>Mycobacterium tuberculosis</i>. We examined the host cell response and replication of <i>Francisella</i> in B6-<i>Slc11a1^G169</i> mice. Bone marrow-derived macrophages from either B6-<i>S2017-01-01T00:00:00Z20172025-04-04T09:00:24.63Z2019-03-27T02:38:38ZS-EPMC53501182836090610.3389/fimmu.2017.00206