{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kasela S"],"funding":["Eesti Teadusagentuur","ERA-Net.Rus","European Research Council","Medical Research Council","National Institute for Health Research (NIHR)","Horizon 2020","Seventh Framework Programme","Wellcome Trust","The European Union through the European Regional Development Fund","Center of Translational Genomics, University of Tartu","Academy of Medical Sciences"],"pagination":["e1006643"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5352142"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and inflammatory diseases. Studies on disease-associated genetic polymorphisms have highlighted the importance of biological context for many regulatory variants, which is particularly relevant in understanding the genetic regulation of the immune system and its cellular phenotypes. Here we show cell type-specific regulation of transcript levels of genes associated with several autoimmune diseases in CD4+ and CD8+ T cells including a trans-acting regulatory locus at chr12q13.2 containing the rs1131017 SNP in the RPS26 gene. Most remarkably, we identify a common missense variant in IL27, associated with type 1 diabetes that results in decreased f"],"journal":["PLoS genetics"],"pubmed_title":["Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells."],"pmcid":["PMC5352142"],"funding_grant_id":["2014-2020.4.01.15-0012","ePerMed (grant no. 692145)","074318","IUT2-2","EGIDA","201488/Z/16/Z","SP1GVARENG","FP7/2007-2013; ERC Grant agreement number 281824","Oxford Biomedical Research Centre","AMS-SGCL13-Fairfax","281824","IUT20-60","BBMRI-LPC (grant no 313010)","98082","CL-2012-13-004","090532/Z/09/Z"],"pubmed_authors":["Tserel L","Franke L","Knight JC","Kasela S","Kisand K","Esko T","Metspalu A","Milani L","Kaleviste E","Westra HJ","Makino S","Fairfax BP","Peterson P","Fischer K","Remm A"],"additional_accession":[]},"is_claimable":false,"name":"Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.","description":"Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and inflammatory diseases. Studies on disease-associated genetic polymorphisms have highlighted the importance of biological context for many regulatory variants, which is particularly relevant in understanding the genetic regulation of the immune system and its cellular phenotypes. Here we show cell type-specific regulation of transcript levels of genes associated with several autoimmune diseases in CD4+ and CD8+ T cells including a trans-acting regulatory locus at chr12q13.2 containing the rs1131017 SNP in the RPS26 gene. Most remarkably, we identify a common missense variant in IL27, associated with type 1 diabetes that results in decreased f","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2026-05-05T10:25:10.543Z","creation":"2019-03-26T22:46:14Z"},"accession":"S-EPMC5352142","cross_references":{"pubmed":["28248954"],"doi":["10.1371/journal.pgen.1006643"]}}