{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Guo W"],"pubmed_abstract":["<h4>Background</h4>Peptidylarginine deiminase (PAD) catalyzes the conversion of arginine residues to citrulline residues, termed citrullination. Recent studies have suggested that PAD isoform 2 (PADI2) plays an important role in tumors, although its tumorigenic effect and mechanism are largely unknown.<h4>Materials and methods</h4>Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were used to investigate the expression level of PADI2 in various tumor tissues and patient blood samples, respectively. MNK-45 and Bel-7402 tumor cell lines originating from gastric and liver tumors, respectively, were treated with anti-PADI2 siRNA, and the subsequent cell proliferation, apoptosis and migration were observed. Polymerase chain reaction (PCR) arrays, including Cancer PathwayFinder,"],"journal":["OncoTargets and therapy"],"pagination":["1475-1485"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5352236"],"repository":["biostudies-literature"],"pubmed_title":["Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors."],"pmcid":["PMC5352236"],"pubmed_authors":["Zheng Y","Li C","Xu B","Guo W","Zhang X","Wang Y","Ma F","Chang X"],"additional_accession":[]},"is_claimable":false,"name":"Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.","description":"<h4>Background</h4>Peptidylarginine deiminase (PAD) catalyzes the conversion of arginine residues to citrulline residues, termed citrullination. Recent studies have suggested that PAD isoform 2 (PADI2) plays an important role in tumors, although its tumorigenic effect and mechanism are largely unknown.<h4>Materials and methods</h4>Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were used to investigate the expression level of PADI2 in various tumor tissues and patient blood samples, respectively. MNK-45 and Bel-7402 tumor cell lines originating from gastric and liver tumors, respectively, were treated with anti-PADI2 siRNA, and the subsequent cell proliferation, apoptosis and migration were observed. Polymerase chain reaction (PCR) arrays, including Cancer PathwayFinder,","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-26T17:32:21.891Z","creation":"2019-03-27T02:38:43Z"},"accession":"S-EPMC5352236","cross_references":{"pubmed":["28331341"],"doi":["10.2147/OTT.S92389"]}}