biostudies-literatureOetjens MTNIGMS NIH HHS853-66https://www.ebi.ac.uk/biostudies/studies/S-EPMC5352965biostudies-literatureUnknown17(8)<h4>Aim</h4>We sought to identify potential pleiotropy involving pharmacogenes.<h4>Methods</h4>We tested 184 functional variants in 34 pharmacogenes for associations using a custom grouping of International Classification and Disease, Ninth Revision billing codes extracted from deidentified electronic health records of 6892 patients.<h4>Results</h4>We replicated several associations including ABCG2 (rs2231142) and gout (p = 1.73 × 10(-7); odds ratio [OR]: 1.73; 95% CI: 1.40-2.12); and SLCO1B1 (rs4149056) and jaundice (p = 2.50 × 10(-4); OR: 1.67; 95% CI: 1.27-2.20).<h4>Conclusion</h4>In this systematic screen for phenotypic associations with functional variants, several novel genotype-phenotype combinations also achieved phenome-wide significance, including SLC15A2 rs1143672 and renal ostePharmacogenomicsEvidence for extensive pleiotropy among pharmacogenes.PMC5352965T32 GM080178Bush WSVerma ADilks HHKodaman NBirdwell KOetjens MTCrawford DCPendergrass SADenny JCRitchie MDfalseEvidence for extensive pleiotropy among pharmacogenes.<h4>Aim</h4>We sought to identify potential pleiotropy involving pharmacogenes.<h4>Methods</h4>We tested 184 functional variants in 34 pharmacogenes for associations using a custom grouping of International Classification and Disease, Ninth Revision billing codes extracted from deidentified electronic health records of 6892 patients.<h4>Results</h4>We replicated several associations including ABCG2 (rs2231142) and gout (p = 1.73 × 10(-7); odds ratio [OR]: 1.73; 95% CI: 1.40-2.12); and SLCO1B1 (rs4149056) and jaundice (p = 2.50 × 10(-4); OR: 1.67; 95% CI: 1.27-2.20).<h4>Conclusion</h4>In this systematic screen for phenotypic associations with functional variants, several novel genotype-phenotype combinations also achieved phenome-wide significance, including SLC15A2 rs1143672 and renal oste2016-01-01T00:00:00Z2016 Jun2026-05-05T19:30:54.269Z2019-03-27T02:38:45ZS-EPMC53529652724951510.2217/pgs-2015-0007