biostudies-literatureHuang HCJiangsu Provincial Bureau of Traditional Chinese Medicine7593027https://www.ebi.ac.uk/biostudies/studies/S-EPMC5352969biostudies-literatureUnknown2017Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on A<i>β</i>_1-42-induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by microdialysis (MD) for <i>in vivo</i> sampling. Meanwhile, the protection of components identified was also verified. At last, we found that Goutengsan has a potential protective effect on A<i>β</i>_1-42-induced PC12 cells via reducing cells damage and increasing cells vitality as well as six components (pachymic acid, liquiritin, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine) which may be effective components. This study helps to undersEvidence-based complementary and alternative medicine : eCAMComponents of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on A<i>β</i>_1-42-Induced PC12 Cells Injury.PMC5352969LZ13083Wang CFXia ZChen JYang NTan XBDong ZBWang JHou XFDi LQGu JFJia XBFeng LZhong RLZhao DHuang HCfalseComponents of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on A<i>β</i>_1-42-Induced PC12 Cells Injury.Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on A<i>β</i>_1-42-induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by microdialysis (MD) for <i>in vivo</i> sampling. Meanwhile, the protection of components identified was also verified. At last, we found that Goutengsan has a potential protective effect on A<i>β</i>_1-42-induced PC12 cells via reducing cells damage and increasing cells vitality as well as six components (pachymic acid, liquiritin, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine) which may be effective components. This study helps to unders2017-01-01T00:00:00Z20172025-04-26T18:45:12.275Z2019-03-27T02:38:45ZS-EPMC53529692834862510.1155/2017/7593027