{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(8)"],"submitter":["Cheong JG"],"pubmed_abstract":["The transmembrane 4 L six family proteins TM4SF1, TM4SF4, and TM4SF5 share 40-50% overall sequence identity, but their C-terminus identity is limited. It may be likely that the C-termini of the members are important and unique for own regulatory functions. We thus examined how the TM4SF5 C-terminus affected cellular functions differentially from other family members. Using colon cancer cells expressing wildtype (WT), C-terminus-deleted, or chimeric mutants, diverse cellular functions were explored in 2-dimensional (2D) and 3-dimensional (3D) condition. The C-termini of the proteins were relatively comparable with respect to 2D cell proliferation, although each C-terminal-deletion mutant exhibited increased proliferation relative to the WT. Using chimeric constructs, we found that the TM4SF"],"journal":["Oncotarget"],"pagination":["13277-13292"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5355095"],"repository":["biostudies-literature"],"pubmed_title":["Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment."],"pmcid":["PMC5355095"],"pubmed_authors":["Song DG","Song HE","Ryu J","Kim HJ","Berditchevski F","Cho CY","Lee JW","Kim S","Cheong JG","Jung JW","Lee KM","Nam SH","Kim JE"],"additional_accession":[]},"is_claimable":false,"name":"Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.","description":"The transmembrane 4 L six family proteins TM4SF1, TM4SF4, and TM4SF5 share 40-50% overall sequence identity, but their C-terminus identity is limited. It may be likely that the C-termini of the members are important and unique for own regulatory functions. We thus examined how the TM4SF5 C-terminus affected cellular functions differentially from other family members. Using colon cancer cells expressing wildtype (WT), C-terminus-deleted, or chimeric mutants, diverse cellular functions were explored in 2-dimensional (2D) and 3-dimensional (3D) condition. The C-termini of the proteins were relatively comparable with respect to 2D cell proliferation, although each C-terminal-deletion mutant exhibited increased proliferation relative to the WT. Using chimeric constructs, we found that the TM4SF","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-19T03:53:10.937Z","creation":"2019-03-27T02:38:51Z"},"accession":"S-EPMC5355095","cross_references":{"pubmed":["28129652"],"doi":["10.18632/oncotarget.14809"]}}