{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(7)"],"submitter":["Ma YS"],"pubmed_abstract":["Increasing evidence supports that microRNA (miRNA) plays a significant functional role in cancer progression by directly regulating respective targets. In this study, the expression levels of miR-105-1 and its target gene were analyzed using genes microarray and hierarchical clustering analysis followed by validation with quantitative RT-PCR in hepatocellular carcinoma (HCC) and normal liver tissues. We examined the expression of nuclear receptor coactivator 1 (NCOA1), the potential target gene of miR-105-1, following the transfection of miR-105-1 mimics or inhibitors. Our results showed that miR-105-1 was downregulated in HCC tissues when compared with normal liver tissues and patients with lower miR-105-1 expression had shorter overall survival (OS) and progression free survival (PFS). M"],"journal":["Oncotarget"],"pagination":["11896-11905"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5355313"],"repository":["biostudies-literature"],"pubmed_title":["High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1."],"pmcid":["PMC5355313"],"pubmed_authors":["Zhong XJ","Chai L","Wu TM","Yang HQ","Cong XL","Lu GX","Xie RT","Ma YS","Chang ZY","Fu D","Zhu J","Lv ZW","Sun R","Cai MX"],"additional_accession":[]},"is_claimable":false,"name":"High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1.","description":"Increasing evidence supports that microRNA (miRNA) plays a significant functional role in cancer progression by directly regulating respective targets. In this study, the expression levels of miR-105-1 and its target gene were analyzed using genes microarray and hierarchical clustering analysis followed by validation with quantitative RT-PCR in hepatocellular carcinoma (HCC) and normal liver tissues. We examined the expression of nuclear receptor coactivator 1 (NCOA1), the potential target gene of miR-105-1, following the transfection of miR-105-1 mimics or inhibitors. Our results showed that miR-105-1 was downregulated in HCC tissues when compared with normal liver tissues and patients with lower miR-105-1 expression had shorter overall survival (OS) and progression free survival (PFS). M","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-19T07:59:51.271Z","creation":"2019-06-06T17:10:24Z"},"accession":"S-EPMC5355313","cross_references":{"pubmed":["28060733"],"doi":["10.18632/oncotarget.14435"]}}