{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oldrati V"],"funding":["Swiss Initiative in Systems Biology (Bridge to Industry)"],"pagination":["e0172966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5357004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Venom based research is exploited to find novel candidates for the development of innovative pharmacological tools, drug candidates and new ingredients for cosmetic and agrochemical industries. Moreover, venomics, as a well-established approach in systems biology, helps to elucidate the genetic mechanisms of the production of such a great molecular biodiversity. Today the advances made in the proteomics, transcriptomics and bioinformatics fields, favor venomics, allowing the in depth study of complex matrices and the elucidation even of minor compounds present in minute biological samples. The present study illustrates a rapid and efficient method developed for the elucidation of venom composition based on NextGen mRNA sequencing of venom glands and LC-MS/MS venom proteome profiling. The a"],"journal":["PloS one"],"pubmed_title":["Peptidomic and transcriptomic profiling of four distinct spider venoms."],"pmcid":["PMC5357004"],"funding_grant_id":["SpidX"],"pubmed_authors":["Oldrati V","Allard PM","Nentwig W","Kuhn-Nentwig L","Lisacek F","Wolfender JL","Koua D","Stocklin R","Arrell M","Hulo N"],"additional_accession":[]},"is_claimable":false,"name":"Peptidomic and transcriptomic profiling of four distinct spider venoms.","description":"Venom based research is exploited to find novel candidates for the development of innovative pharmacological tools, drug candidates and new ingredients for cosmetic and agrochemical industries. Moreover, venomics, as a well-established approach in systems biology, helps to elucidate the genetic mechanisms of the production of such a great molecular biodiversity. Today the advances made in the proteomics, transcriptomics and bioinformatics fields, favor venomics, allowing the in depth study of complex matrices and the elucidation even of minor compounds present in minute biological samples. The present study illustrates a rapid and efficient method developed for the elucidation of venom composition based on NextGen mRNA sequencing of venom glands and LC-MS/MS venom proteome profiling. The a","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-30T08:26:40.406Z","creation":"2019-03-26T22:52:59Z"},"accession":"S-EPMC5357004","cross_references":{"pubmed":["28306751"],"doi":["10.1371/journal.pone.0172966"]}}