{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schindel HS"],"funding":["NIGMS NIH HHS"],"pagination":["e000081"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5359404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(10)"],"pubmed_abstract":["The RegB/RegA two-component system from <i>Rhodobacter capsulatus</i> regulates global changes in gene expression in response to alterations in oxygen levels. Studies have shown that RegB/RegA controls many energy-generating and energy-utilizing systems such as photosynthesis, nitrogen fixation, carbon fixation, hydrogen utilization, respiration, electron transport and denitrification. In this report, we utilized RNA-seq and ChIP-seq to analyse the breadth of genes indirectly and directly regulated by RegA. A comparison of mRNA transcript levels in wild type cells relative to a RegA deletion strain shows that there are 257 differentially expressed genes under photosynthetic defined minimal growth medium conditions and 591 differentially expressed genes when grown photosynthetically in a co"],"journal":["Microbial genomics"],"pubmed_title":["The RegA regulon exhibits variability in response to altered growth conditions and differs markedly between <i>Rhodobacter</i> species."],"pmcid":["PMC5359404"],"funding_grant_id":["R37 GM040941","R01 GM040941"],"pubmed_authors":["Schindel HS","Bauer CE"],"additional_accession":[]},"is_claimable":false,"name":"The RegA regulon exhibits variability in response to altered growth conditions and differs markedly between <i>Rhodobacter</i> species.","description":"The RegB/RegA two-component system from <i>Rhodobacter capsulatus</i> regulates global changes in gene expression in response to alterations in oxygen levels. Studies have shown that RegB/RegA controls many energy-generating and energy-utilizing systems such as photosynthesis, nitrogen fixation, carbon fixation, hydrogen utilization, respiration, electron transport and denitrification. In this report, we utilized RNA-seq and ChIP-seq to analyse the breadth of genes indirectly and directly regulated by RegA. A comparison of mRNA transcript levels in wild type cells relative to a RegA deletion strain shows that there are 257 differentially expressed genes under photosynthetic defined minimal growth medium conditions and 591 differentially expressed genes when grown photosynthetically in a co","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2026-05-30T05:44:36.329Z","creation":"2019-03-27T02:39:08Z"},"accession":"S-EPMC5359404","cross_references":{"pubmed":["28348828"],"doi":["10.1099/mgen.0.000081"]}}