biostudies-literatureSchindel HSNIGMS NIH HHSe000081https://www.ebi.ac.uk/biostudies/studies/S-EPMC5359404biostudies-literatureUnknown2(10)The RegB/RegA two-component system from <i>Rhodobacter capsulatus</i> regulates global changes in gene expression in response to alterations in oxygen levels. Studies have shown that RegB/RegA controls many energy-generating and energy-utilizing systems such as photosynthesis, nitrogen fixation, carbon fixation, hydrogen utilization, respiration, electron transport and denitrification. In this report, we utilized RNA-seq and ChIP-seq to analyse the breadth of genes indirectly and directly regulated by RegA. A comparison of mRNA transcript levels in wild type cells relative to a RegA deletion strain shows that there are 257 differentially expressed genes under photosynthetic defined minimal growth medium conditions and 591 differentially expressed genes when grown photosynthetically in a coMicrobial genomicsThe RegA regulon exhibits variability in response to altered growth conditions and differs markedly between <i>Rhodobacter</i> species.PMC5359404R37 GM040941R01 GM040941Schindel HSBauer CEfalseThe RegA regulon exhibits variability in response to altered growth conditions and differs markedly between <i>Rhodobacter</i> species.The RegB/RegA two-component system from <i>Rhodobacter capsulatus</i> regulates global changes in gene expression in response to alterations in oxygen levels. Studies have shown that RegB/RegA controls many energy-generating and energy-utilizing systems such as photosynthesis, nitrogen fixation, carbon fixation, hydrogen utilization, respiration, electron transport and denitrification. In this report, we utilized RNA-seq and ChIP-seq to analyse the breadth of genes indirectly and directly regulated by RegA. A comparison of mRNA transcript levels in wild type cells relative to a RegA deletion strain shows that there are 257 differentially expressed genes under photosynthetic defined minimal growth medium conditions and 591 differentially expressed genes when grown photosynthetically in a co2016-01-01T00:00:00Z2016 Oct2026-05-30T05:44:36.329Z2019-03-27T02:39:08ZS-EPMC53594042834882810.1099/mgen.0.000081