{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lerch ML"],"funding":["NIA NIH HHS"],"pagination":["160-167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5359782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(3)"],"pubmed_abstract":["Personalized medicine promises diagnosis and treatment of disease at the individual level and relies heavily on clinical specimen integrity and diagnostic assay quality. Preanalytics, the collection and handling steps of a clinical specimen before immunohistochemistry or other clinical assay, are critically important to enable the correct diagnosis of disease. However, the effects of preanalytics are often overlooked due to a lack of standardization and limited assessment tools to quantify their variation. Here, we report a novel real-time ultrasound time-of-flight instrument that is capable of monitoring and imaging the critical step in formalin fixation, diffusion of the fixative into tissue, which provides a quantifiable quality metric for tissue fixation in the clinical laboratory ensu"],"journal":["Applied immunohistochemistry & molecular morphology : AIMM"],"pubmed_title":["Precision Medicine Starts With Preanalytics: Real-Time Assessment of Tissue Fixation Quality by Ultrasound Time-of-Flight Analysis."],"pmcid":["PMC5359782"],"funding_grant_id":["P50 AG005136"],"pubmed_authors":["Chafin D","Theiss A","Otter M","Lerch ML","Baird GS","Bauer DR"],"additional_accession":[]},"is_claimable":false,"name":"Precision Medicine Starts With Preanalytics: Real-Time Assessment of Tissue Fixation Quality by Ultrasound Time-of-Flight Analysis.","description":"Personalized medicine promises diagnosis and treatment of disease at the individual level and relies heavily on clinical specimen integrity and diagnostic assay quality. Preanalytics, the collection and handling steps of a clinical specimen before immunohistochemistry or other clinical assay, are critically important to enable the correct diagnosis of disease. However, the effects of preanalytics are often overlooked due to a lack of standardization and limited assessment tools to quantify their variation. Here, we report a novel real-time ultrasound time-of-flight instrument that is capable of monitoring and imaging the critical step in formalin fixation, diffusion of the fixative into tissue, which provides a quantifiable quality metric for tissue fixation in the clinical laboratory ensu","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2025-04-04T12:39:21.031Z","creation":"2019-03-27T02:39:10Z"},"accession":"S-EPMC5359782","cross_references":{"pubmed":["28027117"],"doi":["10.1097/PAI.0000000000000489"]}}