biostudies-literatureLuo LNational Institute of Environmental Health Sciencesthe Miriam and Jim Mulva Research FundNIEHS NIH HHSNational Cancer Institutea University of Sydney Medical Foundation Program grant and a Michael Smith Foundation for Health Research Infrastructure AwardNCI NIH HHSthe McCarthy Skin Cancer Research Fund and the Marit Peterson Fund for Melanoma ResearchThe University of Texas MD Anderson Cancer Center Various Donors Melanoma and Skin Cancers Priority Program Funde0174234https://www.ebi.ac.uk/biostudies/studies/S-EPMC5360355biostudies-literatureUnknown12(3)The prognostic improvement attributed to genetic markers over current prognostic system has not been well studied for melanoma. The goal of this study is to evaluate the added prognostic value of Vitamin D Pathway (VitD) SNPs to currently known clinical and demographic factors such as age, sex, Breslow thickness, mitosis and ulceration (CDF). We utilized two large independent well-characterized melanoma studies: the Genes, Environment, and Melanoma (GEM) and MD Anderson studies, and performed variable selection of VitD pathway SNPs and CDF using Random Survival Forest (RSF) method in addition to Cox proportional hazards models. The Harrell's C-index was used to compare the performance of model predictability. The population-based GEM study enrolled 3,578 incident cases of cutaneous melanomPloS oneNo prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival.PMC5360355R01 CA112524P30 CA008748P30 ES010126R01CA112243, R01CA112243-05S1, R33CA10704339P30CA016086, P30CA008748, P30CA014089, P30CA118100P30 CA014089R01CA098438P30 CA016086U01 CA083180P50 CA093459P30ES010126R01CA112524, R01CA112524-05S2,U01CA83180R01 CA112243R01 CA098438P30 CA118100Orlow ILee JEGEM Study GroupLuo LKanetsky PAFang SThomas NEBerwick MLee JHfalseNo prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival.The prognostic improvement attributed to genetic markers over current prognostic system has not been well studied for melanoma. The goal of this study is to evaluate the added prognostic value of Vitamin D Pathway (VitD) SNPs to currently known clinical and demographic factors such as age, sex, Breslow thickness, mitosis and ulceration (CDF). We utilized two large independent well-characterized melanoma studies: the Genes, Environment, and Melanoma (GEM) and MD Anderson studies, and performed variable selection of VitD pathway SNPs and CDF using Random Survival Forest (RSF) method in addition to Cox proportional hazards models. The Harrell's C-index was used to compare the performance of model predictability. The population-based GEM study enrolled 3,578 incident cases of cutaneous melanom2017-01-01T00:00:00Z20172026-05-30T10:35:51.192Z2019-03-26T22:53:00ZS-EPMC53603552832390210.1371/journal.pone.0174234