{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Spinetti G"],"funding":["British Heart Foundation","Telethon"],"pagination":["370-380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5361669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(2)"],"pubmed_abstract":["The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of <i>BPIFB4</i> and ischemia-responding HIF-1α pathway components (i.e. <i>CXCR4</i>, <i>AK3, ALDO-C, ADM</i>, <i>VEGF-A</i>, <i>GLUT-1</i> and miR-210) with human life-span and health-span by analyzing mRNA expression in circulating mononuclear cells (MNCs) of LLIs (N=14 healthy; N=31 frail) and young controls (N=63).<i>ALDO-C, ADM</i>, <i>VEGF-A</i> and <i>GLUT-1</i> significantly decreased and miR-210 increased"],"journal":["Aging"],"pubmed_title":["The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy."],"pmcid":["PMC5361669"],"funding_grant_id":["PG/15/54/31559","GGP14092"],"pubmed_authors":["Specchia C","Vecchione C","Puca AA","Spinelli C","Madeddu P","Carrizzo A","Spinetti G","Pipolo R","Greco S","Martelli F","Villa F","Voellenkle C","Sangalli E"],"additional_accession":[]},"is_claimable":false,"name":"The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy.","description":"The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of <i>BPIFB4</i> and ischemia-responding HIF-1α pathway components (i.e. <i>CXCR4</i>, <i>AK3, ALDO-C, ADM</i>, <i>VEGF-A</i>, <i>GLUT-1</i> and miR-210) with human life-span and health-span by analyzing mRNA expression in circulating mononuclear cells (MNCs) of LLIs (N=14 healthy; N=31 frail) and young controls (N=63).<i>ALDO-C, ADM</i>, <i>VEGF-A</i> and <i>GLUT-1</i> significantly decreased and miR-210 increased","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-04-04T11:14:45.181Z","creation":"2019-03-27T02:39:15Z"},"accession":"S-EPMC5361669","cross_references":{"pubmed":["28121621"],"doi":["10.18632/aging.101159"]}}