biostudies-literatureSpinetti GBritish Heart FoundationTelethon370-380https://www.ebi.ac.uk/biostudies/studies/S-EPMC5361669biostudies-literatureUnknown9(2)The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of <i>BPIFB4</i> and ischemia-responding HIF-1α pathway components (i.e. <i>CXCR4</i>, <i>AK3, ALDO-C, ADM</i>, <i>VEGF-A</i>, <i>GLUT-1</i> and miR-210) with human life-span and health-span by analyzing mRNA expression in circulating mononuclear cells (MNCs) of LLIs (N=14 healthy; N=31 frail) and young controls (N=63).<i>ALDO-C, ADM</i>, <i>VEGF-A</i> and <i>GLUT-1</i> significantly decreased and miR-210 increasedAgingThe expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy.PMC5361669PG/15/54/31559GGP14092Specchia CVecchione CPuca AASpinelli CMadeddu PCarrizzo ASpinetti GPipolo RGreco SMartelli FVilla FVoellenkle CSangalli EfalseThe expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy.The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of <i>BPIFB4</i> and ischemia-responding HIF-1α pathway components (i.e. <i>CXCR4</i>, <i>AK3, ALDO-C, ADM</i>, <i>VEGF-A</i>, <i>GLUT-1</i> and miR-210) with human life-span and health-span by analyzing mRNA expression in circulating mononuclear cells (MNCs) of LLIs (N=14 healthy; N=31 frail) and young controls (N=63).<i>ALDO-C, ADM</i>, <i>VEGF-A</i> and <i>GLUT-1</i> significantly decreased and miR-210 increased2017-01-01T00:00:00Z2017 Jan2025-04-04T11:14:45.181Z2019-03-27T02:39:15ZS-EPMC53616692812162110.18632/aging.101159