{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chung JJ"],"funding":["Yale School of Medicine","Howard Hughes Medical Institute"],"pagination":["e23082"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5362262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["We report that the <i>Gm7068</i> (<i>CatSpere</i>) and <i>Tex40</i> (<i>CatSperz</i>) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of <i>CatSperz</i> reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm intervals along the flagellum. This disruption renders the proximal flagellum inflexible and alters the 3D flagellar envelope, thus preventing sperm from reorienting against fluid flow <i>in vitro</i> and efficiently migrating <i>in vivo</i>. Ejaculated <i>CatSperz</i>-null sperm cells retrieved from the mated female uterus partially rescue <i>in vitro</i> fertiliza"],"journal":["eLife"],"pubmed_title":["CatSperζ regulates the structural continuity of sperm Ca<sup>2+</sup> signaling domains and is required for normal fertility."],"pmcid":["PMC5362262"],"funding_grant_id":["Goodman-Gilman Yale Scholar Award 2015-08"],"pubmed_authors":["Kim D","Clapham DE","Iseri Y","Shi HF","Zhuang X","Hwang JY","Shim SH","Miki K","Chung JJ","Cai X"],"additional_accession":[]},"is_claimable":false,"name":"CatSperζ regulates the structural continuity of sperm Ca<sup>2+</sup> signaling domains and is required for normal fertility.","description":"We report that the <i>Gm7068</i> (<i>CatSpere</i>) and <i>Tex40</i> (<i>CatSperz</i>) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of <i>CatSperz</i> reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm intervals along the flagellum. This disruption renders the proximal flagellum inflexible and alters the 3D flagellar envelope, thus preventing sperm from reorienting against fluid flow <i>in vitro</i> and efficiently migrating <i>in vivo</i>. Ejaculated <i>CatSperz</i>-null sperm cells retrieved from the mated female uterus partially rescue <i>in vitro</i> fertiliza","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-04-08T04:03:36.685Z","creation":"2019-03-27T02:39:16Z"},"accession":"S-EPMC5362262","cross_references":{"pubmed":["28226241"],"doi":["10.7554/eLife.23082"]}}