biostudies-literatureCreutz SENIH Office of the DirectorGordon and Betty Moore FoundationNIGMS NIH HHS2321-2328https://www.ebi.ac.uk/biostudies/studies/S-EPMC5363375biostudies-literatureUnknown8(3)Hydrogen bonding and other types of secondary-sphere interactions are ubiquitous in metalloenzyme active sites and are critical to the transformations they mediate. Exploiting secondary sphere interactions in synthetic catalysts to study the role(s) they might play in biological systems, and to develop increasingly efficient catalysts, is an important challenge. Whereas model studies in this broad context are increasingly abundant, as yet there has been relatively little progress in the area of synthetic catalysts for nitrogen fixation that incorporate secondary sphere design elements. Herein we present our first study of Fe-N _<i>x</i> H _<i>y</i> complexes supported by new tris(phosphine)silyl ligands, abbreviated as [SiPNMe3] and [SiPiPr2P^NMe], that incorpChemical scienceExploring secondary-sphere interactions in Fe-N _<i>x</i> H _<i>y</i> complexes relevant to N₂ fixation.PMC5363375GM 070757R01 GM070757Peters JCCreutz SEfalseExploring secondary-sphere interactions in Fe-N _<i>x</i> H _<i>y</i> complexes relevant to N₂ fixation.Hydrogen bonding and other types of secondary-sphere interactions are ubiquitous in metalloenzyme active sites and are critical to the transformations they mediate. Exploiting secondary sphere interactions in synthetic catalysts to study the role(s) they might play in biological systems, and to develop increasingly efficient catalysts, is an important challenge. Whereas model studies in this broad context are increasingly abundant, as yet there has been relatively little progress in the area of synthetic catalysts for nitrogen fixation that incorporate secondary sphere design elements. Herein we present our first study of Fe-N _<i>x</i> H _<i>y</i> complexes supported by new tris(phosphine)silyl ligands, abbreviated as [SiPNMe3] and [SiPiPr2P^NMe], that incorp2017-01-01T00:00:00Z2017 Mar2025-04-04T09:01:32.9Z2019-03-27T02:39:23ZS-EPMC53633752845133610.1039/c6sc04805f