{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Albino D"],"funding":["Swiss National Science Foundation"],"pagination":["76756-76768"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5363547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(47)"],"pubmed_abstract":["Metastatic prostate cancer represents a yet unsolved clinical problem due to the high frequency of relapse and treatment resistance. Understanding the pathways that lead to prostate cancer progression is an important task to prevent this deadly disease. The ETS transcription factor ESE3/EHF has an important role in differentiation of human prostate epithelial cells. Loss of ESE3/EHF in prostate epithelial cells determines transformation, epithelial-to-mesenchymal transition (EMT) and acquisition of stem-like properties. In this study we identify IL-6 as a direct target of ESE3/EHF that is activated in prostate epithelial cells upon loss of ESE3/EHF. ESE3/EHF and IL-6 were significantly inversely correlated in prostate tumors. Chromatin immunoprecipitation confirmed binding of ESE3/EHF to a"],"journal":["Oncotarget"],"pubmed_title":["The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment."],"pmcid":["PMC5363547"],"funding_grant_id":["310030","146560"],"pubmed_authors":["Catapano CV","Albino D","Civenni G","Carbone GM","Rossi S","Mitra A"],"additional_accession":[]},"is_claimable":false,"name":"The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.","description":"Metastatic prostate cancer represents a yet unsolved clinical problem due to the high frequency of relapse and treatment resistance. Understanding the pathways that lead to prostate cancer progression is an important task to prevent this deadly disease. The ETS transcription factor ESE3/EHF has an important role in differentiation of human prostate epithelial cells. Loss of ESE3/EHF in prostate epithelial cells determines transformation, epithelial-to-mesenchymal transition (EMT) and acquisition of stem-like properties. In this study we identify IL-6 as a direct target of ESE3/EHF that is activated in prostate epithelial cells upon loss of ESE3/EHF. ESE3/EHF and IL-6 were significantly inversely correlated in prostate tumors. Chromatin immunoprecipitation confirmed binding of ESE3/EHF to a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-04T09:00:41.057Z","creation":"2019-03-27T02:39:24Z"},"accession":"S-EPMC5363547","cross_references":{"pubmed":["27732936"],"doi":["10.18632/oncotarget.12525"]}}