{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Demoin DW"],"funding":["NCI NIH HHS"],"pagination":["606-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5363724"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(10)"],"pubmed_abstract":["<h4>Introduction</h4>Chemokine receptor-4 (CXCR4, fusin, CD184) is expressed on several tissues involved in immune regulation and is upregulated in many diseases including malignant gliomas. A radiolabeled small molecule that readily crosses the blood-brain barrier can aid in identifying CXCR4-expressing gliomas and monitoring CXCR4-targeted therapy. In the current work, we have synthesized and evaluated an [(18)F]-labeled small molecule based on a pyrimidine-pyridine amine for its ability to target CXCR4.<h4>Experimental</h4>The nonradioactive standards and the nitro precursor used in this study were prepared using established methods. An HPLC method was developed to separate the nitro-precursor from the nonradioactive standard and radioactive product. The nitro-precursor was radiolabeled"],"journal":["Nuclear medicine and biology"],"pubmed_title":["Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas."],"pmcid":["PMC5363724"],"funding_grant_id":["R01 CA172546","P50 CA086438","P30 CA008748","R01 CA163980"],"pubmed_authors":["Shindo M","Demoin DW","Pillarsetty NV","Zhang H","Serganova I","Blasberg RG","Edwards KJ","Lewis JS"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.","description":"<h4>Introduction</h4>Chemokine receptor-4 (CXCR4, fusin, CD184) is expressed on several tissues involved in immune regulation and is upregulated in many diseases including malignant gliomas. A radiolabeled small molecule that readily crosses the blood-brain barrier can aid in identifying CXCR4-expressing gliomas and monitoring CXCR4-targeted therapy. In the current work, we have synthesized and evaluated an [(18)F]-labeled small molecule based on a pyrimidine-pyridine amine for its ability to target CXCR4.<h4>Experimental</h4>The nonradioactive standards and the nitro precursor used in this study were prepared using established methods. An HPLC method was developed to separate the nitro-precursor from the nonradioactive standard and radioactive product. The nitro-precursor was radiolabeled","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-04T09:00:49.75Z","creation":"2019-03-27T02:39:25Z"},"accession":"S-EPMC5363724","cross_references":{"pubmed":["27485481"],"doi":["10.1016/j.nucmedbio.2016.05.005"]}}