biostudies-literatureDemoin DWNCI NIH HHS606-11https://www.ebi.ac.uk/biostudies/studies/S-EPMC5363724biostudies-literatureUnknown43(10)<h4>Introduction</h4>Chemokine receptor-4 (CXCR4, fusin, CD184) is expressed on several tissues involved in immune regulation and is upregulated in many diseases including malignant gliomas. A radiolabeled small molecule that readily crosses the blood-brain barrier can aid in identifying CXCR4-expressing gliomas and monitoring CXCR4-targeted therapy. In the current work, we have synthesized and evaluated an [(18)F]-labeled small molecule based on a pyrimidine-pyridine amine for its ability to target CXCR4.<h4>Experimental</h4>The nonradioactive standards and the nitro precursor used in this study were prepared using established methods. An HPLC method was developed to separate the nitro-precursor from the nonradioactive standard and radioactive product. The nitro-precursor was radiolabeledNuclear medicine and biologySynthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.PMC5363724R01 CA172546P50 CA086438P30 CA008748R01 CA163980Shindo MDemoin DWPillarsetty NVZhang HSerganova IBlasberg RGEdwards KJLewis JSfalseSynthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.<h4>Introduction</h4>Chemokine receptor-4 (CXCR4, fusin, CD184) is expressed on several tissues involved in immune regulation and is upregulated in many diseases including malignant gliomas. A radiolabeled small molecule that readily crosses the blood-brain barrier can aid in identifying CXCR4-expressing gliomas and monitoring CXCR4-targeted therapy. In the current work, we have synthesized and evaluated an [(18)F]-labeled small molecule based on a pyrimidine-pyridine amine for its ability to target CXCR4.<h4>Experimental</h4>The nonradioactive standards and the nitro precursor used in this study were prepared using established methods. An HPLC method was developed to separate the nitro-precursor from the nonradioactive standard and radioactive product. The nitro-precursor was radiolabeled2016-01-01T00:00:00Z2016 Oct2025-04-04T09:00:49.75Z2019-03-27T02:39:25ZS-EPMC53637242748548110.1016/j.nucmedbio.2016.05.005