biostudies-literatureWagstaff BABBSRC Institute Strategic Programme on Understanding and Exploiting Metabolism (MET)Biotechnology and Biological Sciences Research CouncilE40https://www.ebi.ac.uk/biostudies/studies/S-EPMC5371795biostudies-literatureUnknown9(3)<i>Prymnesium parvum</i> is a toxin-producing haptophyte that causes harmful algal blooms globally, leading to large-scale fish kills that have severe ecological and economic implications. For the model haptophyte, <i>Emiliania huxleyi</i>, it has been shown that large dsDNA viruses play an important role in regulating blooms and therefore biogeochemical cycling, but much less work has been done looking at viruses that infect <i>P. parvum</i>, or the role that these viruses may play in regulating harmful algal blooms. In this study, we report the isolation and characterization of a lytic nucleo-cytoplasmic large DNA virus (NCLDV) collected from the site of a harmful <i>P. parvum</i> bloom. In subsequent experiments, this virus was shown to infect cultures of <i>Prymnesium</i> sp. and showeVirusesIsolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.PMC53717951366717BB/j004561/1BBS/E/J/000C0618BBS/E/J/000PR9790Barclay JESchroeder DCField RAWagstaff BAVladu ICMalin GfalseIsolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.<i>Prymnesium parvum</i> is a toxin-producing haptophyte that causes harmful algal blooms globally, leading to large-scale fish kills that have severe ecological and economic implications. For the model haptophyte, <i>Emiliania huxleyi</i>, it has been shown that large dsDNA viruses play an important role in regulating blooms and therefore biogeochemical cycling, but much less work has been done looking at viruses that infect <i>P. parvum</i>, or the role that these viruses may play in regulating harmful algal blooms. In this study, we report the isolation and characterization of a lytic nucleo-cytoplasmic large DNA virus (NCLDV) collected from the site of a harmful <i>P. parvum</i> bloom. In subsequent experiments, this virus was shown to infect cultures of <i>Prymnesium</i> sp. and showe2017-01-01T00:00:00Z2017 Mar2026-04-08T16:24:05.026Z2019-03-27T02:39:50ZS-EPMC53717952828293010.3390/v9030040