{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cole SL"],"funding":["Medical Research Council","The Francis Crick Institute","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["e91868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5374077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(7)"],"pubmed_abstract":["In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitalized influenza patients with known risk factors (total of <i>n</i> = 60 patients recruited). We found a sustained increase in a specific subset of proinflammatory monocytes, with high TNF-α expression and an M1-like phenotype (independent of viral titers), in these previously healthy patients with sever"],"journal":["JCI insight"],"pubmed_title":["M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza."],"pmcid":["PMC5374077"],"funding_grant_id":["MC_U117512723","G1001046","MC_U117585868","MC_G1001212","10030","G1000758B","090382/Z/09/Z","MC_UU_12010/1","MR/L018942/1","NF-SI-0513-10150","G0600520","MC_UU_00008/1","G1000758","G0600371","MR/R502121/1"],"pubmed_authors":["Dong T","Openshaw PJ","Thomas C","Kok WL","Benam KH","Barclay W","Drumright L","McCauley J","Liew FY","Taylor S","Bennett M","Powell TJ","Dunning J","Martinez FO","McMichael AJ","Ho LP","Benlahrech A","Cerundolo V","Zambon M","Repapi E","MOSAIC investigators","Cole SL","Elderfield R"],"additional_accession":[]},"is_claimable":false,"name":"M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.","description":"In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitalized influenza patients with known risk factors (total of <i>n</i> = 60 patients recruited). We found a sustained increase in a specific subset of proinflammatory monocytes, with high TNF-α expression and an M1-like phenotype (independent of viral titers), in these previously healthy patients with sever","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2026-05-30T13:45:10.155Z","creation":"2019-03-27T02:39:58Z"},"accession":"S-EPMC5374077","cross_references":{"pubmed":["28405622"],"doi":["10.1172/jci.insight.91868"]}}