{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Lu MC"],"pubmed_abstract":["<i>Klebsiella pneumoniae</i> is the most common pathogen of community-acquired meningitis in Taiwan. However, the lack of a physiologically relevant meningitis model for <i>K. pneumoniae</i> has impeded research into its pathogenesis mechanism. Based on the core genome MLST analyses, the hypervirulent K1 <i>K. pneumoniae</i> strains, which are etiologically implicated in adult meningitis, mostly belong to a single clonal complex, CC23. Some K1 CC23 <i>K. pneumoniae</i> strains carry a gene cluster responsible for colibactin production. Colibactin is a small genotoxic molecule biosynthesized by an NRPS-PKS complex, which is encoded by genes located on the <i>pks</i> island. Compared to other hypervirulent <i>K. pneumoniae</i> which primarily infect the liver, the colibactin-producing (<i>pk"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5374149"],"repository":["biostudies-literature"],"pubmed_title":["Colibactin Contributes to the Hypervirulence of <i>pks</i><sup>+</sup> K1 CC23 <i>Klebsiella pneumoniae</i> in Mouse Meningitis Infections."],"pmcid":["PMC5374149"],"pubmed_authors":["Lai YC","Huang YJ","Chen YT","Wang YC","Liang CL","Lu MC","Hsiao PY","Lin CT","Cheng CC","Chiang MK"],"additional_accession":[]},"is_claimable":false,"name":"Colibactin Contributes to the Hypervirulence of <i>pks</i><sup>+</sup> K1 CC23 <i>Klebsiella pneumoniae</i> in Mouse Meningitis Infections.","description":"<i>Klebsiella pneumoniae</i> is the most common pathogen of community-acquired meningitis in Taiwan. However, the lack of a physiologically relevant meningitis model for <i>K. pneumoniae</i> has impeded research into its pathogenesis mechanism. Based on the core genome MLST analyses, the hypervirulent K1 <i>K. pneumoniae</i> strains, which are etiologically implicated in adult meningitis, mostly belong to a single clonal complex, CC23. Some K1 CC23 <i>K. pneumoniae</i> strains carry a gene cluster responsible for colibactin production. Colibactin is a small genotoxic molecule biosynthesized by an NRPS-PKS complex, which is encoded by genes located on the <i>pks</i> island. Compared to other hypervirulent <i>K. pneumoniae</i> which primarily infect the liver, the colibactin-producing (<i>pk","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-30T13:45:14.122Z","creation":"2019-03-27T02:40:00Z"},"accession":"S-EPMC5374149","cross_references":{"pubmed":["28409125"],"doi":["10.3389/fcimb.2017.00103"]}}