biostudies-literatureUnknown7Lu MC<i>Klebsiella pneumoniae</i> is the most common pathogen of community-acquired meningitis in Taiwan. However, the lack of a physiologically relevant meningitis model for <i>K. pneumoniae</i> has impeded research into its pathogenesis mechanism. Based on the core genome MLST analyses, the hypervirulent K1 <i>K. pneumoniae</i> strains, which are etiologically implicated in adult meningitis, mostly belong to a single clonal complex, CC23. Some K1 CC23 <i>K. pneumoniae</i> strains carry a gene cluster responsible for colibactin production. Colibactin is a small genotoxic molecule biosynthesized by an NRPS-PKS complex, which is encoded by genes located on the <i>pks</i> island. Compared to other hypervirulent <i>K. pneumoniae</i> which primarily infect the liver, the colibactin-producing (<i>pkFrontiers in cellular and infection microbiology103https://www.ebi.ac.uk/biostudies/studies/S-EPMC5374149biostudies-literatureColibactin Contributes to the Hypervirulence of <i>pks</i>⁺ K1 CC23 <i>Klebsiella pneumoniae</i> in Mouse Meningitis Infections.PMC5374149Lai YCHuang YJChen YTWang YCLiang CLLu MCHsiao PYLin CTCheng CCChiang MKfalseColibactin Contributes to the Hypervirulence of <i>pks</i>⁺ K1 CC23 <i>Klebsiella pneumoniae</i> in Mouse Meningitis Infections.<i>Klebsiella pneumoniae</i> is the most common pathogen of community-acquired meningitis in Taiwan. However, the lack of a physiologically relevant meningitis model for <i>K. pneumoniae</i> has impeded research into its pathogenesis mechanism. Based on the core genome MLST analyses, the hypervirulent K1 <i>K. pneumoniae</i> strains, which are etiologically implicated in adult meningitis, mostly belong to a single clonal complex, CC23. Some K1 CC23 <i>K. pneumoniae</i> strains carry a gene cluster responsible for colibactin production. Colibactin is a small genotoxic molecule biosynthesized by an NRPS-PKS complex, which is encoded by genes located on the <i>pks</i> island. Compared to other hypervirulent <i>K. pneumoniae</i> which primarily infect the liver, the colibactin-producing (<i>pk2017-01-01T00:00:00Z20172026-05-30T13:45:14.122Z2019-03-27T02:40:00ZS-EPMC53741492840912510.3389/fcimb.2017.00103