biostudies-literatureUnknown4Kumar RNuclear receptor proteins (NRP) are transcription factor that regulate many vital cellular processes in animal cells. NRPs form a super-family of phylogenetically related proteins and divided into different sub-families on the basis of ligand characteristics and their functions. In the post-genomic era, when new proteins are being added to the database in a high-throughput mode, it becomes imperative to identify new NRPs using information from amino acid sequence alone. In this study we report a SVM based two level prediction systems, NRfamPred, using dipeptide composition of proteins as input. At the 1st level, NRfamPred screens whether the query protein is NRP or non-NRP; if the query protein belongs to NRP class, prediction moves to 2nd level and predicts the sub-family. Using leave-oneScientific reports6810https://www.ebi.ac.uk/biostudies/studies/S-EPMC5381360biostudies-literatureNRfamPred: a proteome-scale two level method for prediction of nuclear receptor proteins and their sub-families.PMC5381360Kumar MKumari BKumar RSrivastava AfalseNRfamPred: a proteome-scale two level method for prediction of nuclear receptor proteins and their sub-families.Nuclear receptor proteins (NRP) are transcription factor that regulate many vital cellular processes in animal cells. NRPs form a super-family of phylogenetically related proteins and divided into different sub-families on the basis of ligand characteristics and their functions. In the post-genomic era, when new proteins are being added to the database in a high-throughput mode, it becomes imperative to identify new NRPs using information from amino acid sequence alone. In this study we report a SVM based two level prediction systems, NRfamPred, using dipeptide composition of proteins as input. At the 1st level, NRfamPred screens whether the query protein is NRP or non-NRP; if the query protein belongs to NRP class, prediction moves to 2nd level and predicts the sub-family. Using leave-one2014-01-01T00:00:00Z2014 Oct2025-04-04T21:39:47.961Z2019-03-27T02:40:26ZS-EPMC53813602535127410.1038/srep06810