{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(2)"],"submitter":["Li N"],"pubmed_abstract":["Our recent study has revealed that the myocardin-related transcription factor-A (MRTF-A) is involved in the apoptosis of cortical neurons induced by ischemia/reperfusion (I/R). Histone deacetylase 5 (HDAC5) and histone acetyltransferase p300 (P300) are two well-known regulators for transcription factors; however, their roles in MRTF-A-related effect on neuronal injuries during I/R are still unclear. In this study, in a model rat cerebral I/R injury via middle cerebral artery occlusion and reperfusion, we found that the expression and activity of HDAC5 was upregulated, whereas p300 and MRTF-A were downregulated both in expression and activity during I/R. Their expression changes and the interaction of the MRTF-A with HDAC5 or p300 were further verified by double immunofluorescence and co-im"],"journal":["Cell death & disease"],"pagination":["e2624"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5386465"],"repository":["biostudies-literature"],"pubmed_title":["Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats."],"pmcid":["PMC5386465"],"pubmed_authors":["Hu XM","Zhang Y","Yuan Q","Xu SQ","Zhang C","Cao XL","Li N","Min ZL","Yu ZJ","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats.","description":"Our recent study has revealed that the myocardin-related transcription factor-A (MRTF-A) is involved in the apoptosis of cortical neurons induced by ischemia/reperfusion (I/R). Histone deacetylase 5 (HDAC5) and histone acetyltransferase p300 (P300) are two well-known regulators for transcription factors; however, their roles in MRTF-A-related effect on neuronal injuries during I/R are still unclear. In this study, in a model rat cerebral I/R injury via middle cerebral artery occlusion and reperfusion, we found that the expression and activity of HDAC5 was upregulated, whereas p300 and MRTF-A were downregulated both in expression and activity during I/R. Their expression changes and the interaction of the MRTF-A with HDAC5 or p300 were further verified by double immunofluorescence and co-im","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-19T19:40:02.158Z","creation":"2019-03-27T02:40:56Z"},"accession":"S-EPMC5386465","cross_references":{"pubmed":["28230854"],"doi":["10.1038/cddis.2017.16"]}}