{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(2)"],"submitter":["Scudiero I"],"pubmed_abstract":["The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause psoriasis in a dominant manner and with high penetrancy. Here, we demonstrate that in human keratinocytes CARMA2sh plays an essential role in the signal transduction pathway that connects pathogen-associated molecular patterns recognition to NF-κB activation. We also find that the serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh, thereby inhibiting its capacity to activate NF-κB by promoting lysosomal degradation of BCL10, which is essential for CARMA2sh-medi"],"journal":["Cell death & disease"],"pagination":["e2627"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5386493"],"repository":["biostudies-literature"],"pubmed_title":["CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship."],"pmcid":["PMC5386493"],"pubmed_authors":["Vito P","Scudiero I","De Rubis G","Ferravante A","Pizzulo M","D'Andrea LE","Zotti T","Reale C","Muralitharan S","Mazzone P","Stilo R","Telesio G"],"additional_accession":[]},"is_claimable":false,"name":"CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.","description":"The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause psoriasis in a dominant manner and with high penetrancy. Here, we demonstrate that in human keratinocytes CARMA2sh plays an essential role in the signal transduction pathway that connects pathogen-associated molecular patterns recognition to NF-κB activation. We also find that the serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh, thereby inhibiting its capacity to activate NF-κB by promoting lysosomal degradation of BCL10, which is essential for CARMA2sh-medi","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-19T19:42:07.585Z","creation":"2019-03-27T02:40:54Z"},"accession":"S-EPMC5386493","cross_references":{"pubmed":["28230860"],"doi":["10.1038/cddis.2017.51"]}}