{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Guerriero I"],"pubmed_abstract":["Hyperactivation of the PI3K/AKT pathway is observed in most human cancer including lung carcinomas. Here we have investigated the role of miRNAs as downstream targets of activated PI3K/AKT signaling in Non Small Cell Lung Cancer (NSCLC). To this aim, miRNA profiling was performed in human lung epithelial cells (BEAS-2B) expressing active AKT1 (BEAS-AKT1-E17K), active PI3KCA (BEAS-PIK3CA-E545K) or with silenced PTEN (BEAS-shPTEN).Twenty-four differentially expressed miRNAs common to BEAS-AKT1-E17K, BEAS-PIK3CA-E545K and BEAS-shPTEN cells were identified through this analysis, with miR-196a being the most consistently up-regulated miRNA. Interestingly, miR-196a was significantly overexpressed also in human NSCLC-derived cell lines (n=11) and primary lung cancer samples (n=28).By manipulating"],"journal":["Oncotarget"],"pagination":["19172-19191"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5386676"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells."],"pmcid":["PMC5386676"],"pubmed_authors":["Guerriero I","Scrima M","Ceccarelli M","Santos M","De Marco C","Ravo M","Malanga D","Rizzuto A","Pallante P","Weisz A","D'Angelo D","Viglietto G","Laudanna C","Falco G"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells.","description":"Hyperactivation of the PI3K/AKT pathway is observed in most human cancer including lung carcinomas. Here we have investigated the role of miRNAs as downstream targets of activated PI3K/AKT signaling in Non Small Cell Lung Cancer (NSCLC). To this aim, miRNA profiling was performed in human lung epithelial cells (BEAS-2B) expressing active AKT1 (BEAS-AKT1-E17K), active PI3KCA (BEAS-PIK3CA-E545K) or with silenced PTEN (BEAS-shPTEN).Twenty-four differentially expressed miRNAs common to BEAS-AKT1-E17K, BEAS-PIK3CA-E545K and BEAS-shPTEN cells were identified through this analysis, with miR-196a being the most consistently up-regulated miRNA. Interestingly, miR-196a was significantly overexpressed also in human NSCLC-derived cell lines (n=11) and primary lung cancer samples (n=28).By manipulating","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2026-05-30T12:42:24.812Z","creation":"2019-03-27T02:40:57Z"},"accession":"S-EPMC5386676","cross_references":{"pubmed":["27880728"],"doi":["10.18632/oncotarget.13432"]}}