{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stokes BA"],"funding":["National Center for Research Resources","CRI and NIH","NICHD NIH HHS","NCRR NIH HHS","Eunice Kennedy Shriver National Institute of Child Health &amp; Human Development","Board of Visitors to the Children&apos;s National Medical Center"],"pagination":["81-91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5388561"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(2)"],"pubmed_abstract":["<h4>Background</h4>Periconception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.<h4>Methods</h4>We determined the effect of periconception iron and/or folic acid supplementation on the penetrance o"],"journal":["Birth defects research"],"pubmed_title":["High levels of iron supplementation prevents neural tube defects in the Fpn1<sup>ffe</sup> mouse model."],"pmcid":["PMC5388561"],"funding_grant_id":["R21-HD076202","R21 HD076202","P30HD040677","UL1RR031988","P30 HD040677","U54 HD090257","UL1 RR031988"],"pubmed_authors":["Stokes BA","Zohn IE","Sabatino JA"],"additional_accession":[]},"is_claimable":false,"name":"High levels of iron supplementation prevents neural tube defects in the Fpn1<sup>ffe</sup> mouse model.","description":"<h4>Background</h4>Periconception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.<h4>Methods</h4>We determined the effect of periconception iron and/or folic acid supplementation on the penetrance o","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-04-19T08:26:42.268Z","creation":"2019-03-26T22:58:58Z"},"accession":"S-EPMC5388561","cross_references":{"pubmed":["28008752"],"doi":["10.1002/bdra.23542"]}}