biostudies-literatureCheepurupalli LScience and Engineering Research Board614https://www.ebi.ac.uk/biostudies/studies/S-EPMC5388697biostudies-literatureUnknown8The emergence and spread of multi-drug resistant (MDR) especially carbapenem-resistant <i>Klebsiella pneumoniae</i> is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. MDR <i>K. pneumoniae</i> manifests all broad mechanisms of drug resistance, hence development of new drugs to treat MDR <i>K. pneumoniae</i> infection has become a more relevant question in the scientific community. In the present study a potential <i>Streptomyces</i> sp. ASK2 was isolated from rhizosphere soil of medicinal plant. The multistep HPLC purification identified the active principle exhibiting antagonistic activity against MDR <i>K. pneumoniae</i>. The purified compound was found to be an aromatic compound with aliphatic side chain molecule having a molecular weight Frontiers in microbiologyBioactive Molecule from <i>Streptomyces</i> sp. Mitigates MDR <i>Klebsiella pneumoniae</i> in Zebrafish Infection Model.PMC5388697SR/SO/HS-0073/2012Rathore SSCheepurupalli LRamakrishnan JRaman TfalseBioactive Molecule from <i>Streptomyces</i> sp. Mitigates MDR <i>Klebsiella pneumoniae</i> in Zebrafish Infection Model.The emergence and spread of multi-drug resistant (MDR) especially carbapenem-resistant <i>Klebsiella pneumoniae</i> is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. MDR <i>K. pneumoniae</i> manifests all broad mechanisms of drug resistance, hence development of new drugs to treat MDR <i>K. pneumoniae</i> infection has become a more relevant question in the scientific community. In the present study a potential <i>Streptomyces</i> sp. ASK2 was isolated from rhizosphere soil of medicinal plant. The multistep HPLC purification identified the active principle exhibiting antagonistic activity against MDR <i>K. pneumoniae</i>. The purified compound was found to be an aromatic compound with aliphatic side chain molecule having a molecular weight 2017-01-01T00:00:00Z20172026-04-08T16:52:54.046Z2019-03-27T02:41:04ZS-EPMC53886972844690010.3389/fmicb.2017.00614