{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Xing X"],"pubmed_abstract":["<h4>Background</h4>OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.<h4>Methods</h4>We assessed expression and biological behavior of OPCML in gastric cancer.<h4>Results</h4>OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p < 0.001). Furthermore, the results revealed that OPCML was an independent prognostic factor for overall survival in gastric cancer (p = 0.002). In addition, ectopic expression of OPCML in cancer cells significantly inhibited cell viability (p < 0.01) and colony formation (p < 0.001)"],"journal":["BMC cancer"],"pagination":["268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5391589"],"repository":["biostudies-literature"],"pubmed_title":["Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer."],"pmcid":["PMC5391589"],"pubmed_authors":["Ma S","Yang Y","Liu L","Chen M","Xing X","Zhang X","Wang Y","Jiao J","Shi H","Li M","Cai W"],"additional_accession":[]},"is_claimable":false,"name":"Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.","description":"<h4>Background</h4>OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.<h4>Methods</h4>We assessed expression and biological behavior of OPCML in gastric cancer.<h4>Results</h4>OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p < 0.001). Furthermore, the results revealed that OPCML was an independent prognostic factor for overall survival in gastric cancer (p = 0.002). In addition, ectopic expression of OPCML in cancer cells significantly inhibited cell viability (p < 0.01) and colony formation (p < 0.001)","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2026-07-09T10:35:26.144Z","creation":"2026-07-09T10:26:03.864Z"},"accession":"S-EPMC5391589","cross_references":{"pubmed":["28407749"],"doi":["10.1186/s12885-017-3203-y"]}}