biostudies-literatureUnknown17(1)Xing X<h4>Background</h4>OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.<h4>Methods</h4>We assessed expression and biological behavior of OPCML in gastric cancer.<h4>Results</h4>OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p < 0.001). Furthermore, the results revealed that OPCML was an independent prognostic factor for overall survival in gastric cancer (p = 0.002). In addition, ectopic expression of OPCML in cancer cells significantly inhibited cell viability (p < 0.01) and colony formation (p < 0.001)BMC cancer268https://www.ebi.ac.uk/biostudies/studies/S-EPMC5391589biostudies-literatureDown-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.PMC5391589Ma SYang YLiu LChen MXing XZhang XWang YJiao JShi HLi MCai WfalseDown-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.<h4>Background</h4>OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.<h4>Methods</h4>We assessed expression and biological behavior of OPCML in gastric cancer.<h4>Results</h4>OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p < 0.001). Furthermore, the results revealed that OPCML was an independent prognostic factor for overall survival in gastric cancer (p = 0.002). In addition, ectopic expression of OPCML in cancer cells significantly inhibited cell viability (p < 0.01) and colony formation (p < 0.001)2017-01-01T00:00:00Z2017 Apr2026-07-09T10:35:26.144Z2026-07-09T10:26:03.864ZS-EPMC53915892840774910.1186/s12885-017-3203-y