{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chia YY"],"funding":["National Science Council"],"pagination":["4792489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5392408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2017"],"pubmed_abstract":["<i>Background</i>. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. <i>Objectives</i>. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1<i>β</i>, and tumor necrosis factor <i>α</i> (TNF-<i>α</i>). <i>Methods</i>. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. <i>Results</i>. LE"],"journal":["Pain research & management"],"pubmed_title":["The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines."],"pmcid":["PMC5392408"],"funding_grant_id":["EDAHP 104028","EDPJ 105079","NCKUEDA 10503","EDPJ 104068","EDPJ 105081","105-2314-B-214-002-MY3","103-2314-B-214-003-MY3"],"pubmed_authors":["Liu CC","Feng GM","Hung KC","Tan PH","Tseng CA","Chen CC","Chia YY"],"additional_accession":[]},"is_claimable":false,"name":"The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines.","description":"<i>Background</i>. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. <i>Objectives</i>. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1<i>β</i>, and tumor necrosis factor <i>α</i> (TNF-<i>α</i>). <i>Methods</i>. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. <i>Results</i>. LE","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-05-31T23:15:45.909Z","creation":"2020-11-19T11:17:15Z"},"accession":"S-EPMC5392408","cross_references":{"pubmed":["28469528"],"doi":["10.1155/2017/4792489"]}}