biostudies-literatureChia YYNational Science Council4792489https://www.ebi.ac.uk/biostudies/studies/S-EPMC5392408biostudies-literatureUnknown2017<i>Background</i>. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. <i>Objectives</i>. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1<i>β</i>, and tumor necrosis factor <i>α</i> (TNF-<i>α</i>). <i>Methods</i>. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. <i>Results</i>. LEPain research & managementThe Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines.PMC5392408EDAHP 104028EDPJ 105079NCKUEDA 10503EDPJ 104068EDPJ 105081105-2314-B-214-002-MY3103-2314-B-214-003-MY3Liu CCFeng GMHung KCTan PHTseng CAChen CCChia YYfalseThe Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines.<i>Background</i>. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. <i>Objectives</i>. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1<i>β</i>, and tumor necrosis factor <i>α</i> (TNF-<i>α</i>). <i>Methods</i>. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. <i>Results</i>. LE2017-01-01T00:00:00Z20172025-05-31T23:15:45.909Z2020-11-19T11:17:15ZS-EPMC53924082846952810.1155/2017/4792489