{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kibaly C"],"funding":["NIDA NIH HHS","National Institutes of Health"],"pagination":["153-168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5392433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119"],"pubmed_abstract":["The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-protein-coupled receptors (GPCR) phosphorylation and desensitization increase. Because morphine desensitization previously has been shown to be MOR phosphorylation- and ß-arrestin2-independent (in contrast to agonists such as fentanyl), we examined the contribution of phosphorylation of the entire C-terminus to the development of antinociceptive tolerance to the partial (morphine) and full (fentanyl) MOR agonists in vivo. In MOR knockout (MORKO) mice, we delivered via lentivirus the genes encodin"],"journal":["Pharmacological research"],"pubmed_title":["Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo."],"pmcid":["PMC5392433"],"funding_grant_id":["DA031442","P50 DA011806","R01 DA031442","DA011806"],"pubmed_authors":["Kibaly C","Loh HH","Lin HY","Law PY"],"additional_accession":[]},"is_claimable":false,"name":"Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.","description":"The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-protein-coupled receptors (GPCR) phosphorylation and desensitization increase. Because morphine desensitization previously has been shown to be MOR phosphorylation- and ß-arrestin2-independent (in contrast to agonists such as fentanyl), we examined the contribution of phosphorylation of the entire C-terminus to the development of antinociceptive tolerance to the partial (morphine) and full (fentanyl) MOR agonists in vivo. In MOR knockout (MORKO) mice, we delivered via lentivirus the genes encodin","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2025-04-04T02:12:05.683Z","creation":"2019-03-26T23:33:50Z"},"accession":"S-EPMC5392433","cross_references":{"pubmed":["28179123"],"doi":["10.1016/j.phrs.2017.01.033"]}}