biostudies-literatureDinakarpandian DNIBIB NIH HHS2https://www.ebi.ac.uk/biostudies/studies/S-EPMC539358biostudies-literatureUnknown4(1)BACKGROUND: The amino acid composition of a low molecular weight chromium binding peptide (LMWCr), isolated from bovine liver, is reportedly E:G:C:D::4:2:2:2, though its sequence has not been discovered. There is some controversy surrounding the exact biochemical forms and the action of Cr(III) in biological systems; the topic has been the subject of many experimental reports and continues to be investigated. Clarification of Cr-protein interactions will further understanding Cr(III) biochemistry and provide a basis for novel therapies based on metallocomplexes or small molecules. RESULTS: A genomic search of the non-redundant database for all possible decapeptides of the reported composition yields three exact matches, EDGEECDCGE, DGEECDCGEE and CEGGCEEDDE. The first two sequences are fouBMC chemical biologyAn informatics search for the low-molecular weight chromium-binding peptide.PMC539358P41 EB001980Van Horn JDAmini KChaudhary SBennett BDinakarpandian DMorrissette VfalseAn informatics search for the low-molecular weight chromium-binding peptide.BACKGROUND: The amino acid composition of a low molecular weight chromium binding peptide (LMWCr), isolated from bovine liver, is reportedly E:G:C:D::4:2:2:2, though its sequence has not been discovered. There is some controversy surrounding the exact biochemical forms and the action of Cr(III) in biological systems; the topic has been the subject of many experimental reports and continues to be investigated. Clarification of Cr-protein interactions will further understanding Cr(III) biochemistry and provide a basis for novel therapies based on metallocomplexes or small molecules. RESULTS: A genomic search of the non-redundant database for all possible decapeptides of the reported composition yields three exact matches, EDGEECDCGE, DGEECDCGEE and CEGGCEEDDE. The first two sequences are fou2004-01-01T00:00:00Z2004 Dec2026-05-03T18:48:22.286Z2019-03-27T01:08:26ZS-EPMC5393581560358710.1186/1472-6769-4-2