biostudies-literatureUnknown11(4)Faucon F<h4>Background</h4>The capacity of Aedes mosquitoes to resist chemical insecticides threatens the control of major arbovirus diseases worldwide. Until alternative control tools are widely deployed, monitoring insecticide resistance levels and identifying resistance mechanisms in field mosquito populations is crucial for implementing appropriate management strategies. Metabolic resistance to pyrethroids is common in Aedes aegypti but the monitoring of the dynamics of resistant alleles is impeded by the lack of robust genomic markers.<h4>Methodology/principal findings</h4>In an attempt to identify the genomic bases of metabolic resistance to deltamethrin, multiple resistant and susceptible populations originating from various continents were compared using both RNA-seq and a targeted DNA-seqPLoS neglected tropical diseasese0005526https://www.ebi.ac.uk/biostudies/studies/S-EPMC5393893biostudies-literatureIn the hunt for genomic markers of metabolic resistance to pyrethroids in the mosquito Aedes aegypti: An integrated next-generation sequencing approach.PMC5393893Gaude TPoupardin RFaucon FNavratil VBoyer FDusfour ICorbel VGirod RJuntarajumnong WReynaud SDavid JPfalseIn the hunt for genomic markers of metabolic resistance to pyrethroids in the mosquito Aedes aegypti: An integrated next-generation sequencing approach.<h4>Background</h4>The capacity of Aedes mosquitoes to resist chemical insecticides threatens the control of major arbovirus diseases worldwide. Until alternative control tools are widely deployed, monitoring insecticide resistance levels and identifying resistance mechanisms in field mosquito populations is crucial for implementing appropriate management strategies. Metabolic resistance to pyrethroids is common in Aedes aegypti but the monitoring of the dynamics of resistant alleles is impeded by the lack of robust genomic markers.<h4>Methodology/principal findings</h4>In an attempt to identify the genomic bases of metabolic resistance to deltamethrin, multiple resistant and susceptible populations originating from various continents were compared using both RNA-seq and a targeted DNA-seq2017-01-01T00:00:00Z2017 Apr2025-04-21T23:42:02.799Z2019-03-27T02:41:27ZS-EPMC53938932837996910.1371/journal.pntd.0005526