biostudies-literatureUnknown12(4)Grondahl MLThis multicenter cohort study on embryo assessment and outcome data from 11,744 IVF/ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women's age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding factors as center, partner's age and referral diagnosis. Cycle outcome data confirmed the well-known effect of women's age. Oocyte nuclear maturation and proportion of 2 pro-nuclear (2PN) zygotes were not affected by age, while a significant increase in 3PN zygotes was observed in both IVF and ICSI (p<0.0001) with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly, initial hCG value after single embryo transfer foPloS onee0172456https://www.ebi.ac.uk/biostudies/studies/S-EPMC5396884biostudies-literatureEffect of women's age on embryo morphology, cleavage rate and competence-A multicenter cohort study.PMC5396884Christiansen SLRaaschou-Jensen MAgerholm IEGrondahl MLLemmen JGLundstrom PBogstad JLadelund SKesmodel USfalseEffect of women's age on embryo morphology, cleavage rate and competence-A multicenter cohort study.This multicenter cohort study on embryo assessment and outcome data from 11,744 IVF/ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women's age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding factors as center, partner's age and referral diagnosis. Cycle outcome data confirmed the well-known effect of women's age. Oocyte nuclear maturation and proportion of 2 pro-nuclear (2PN) zygotes were not affected by age, while a significant increase in 3PN zygotes was observed in both IVF and ICSI (p<0.0001) with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly, initial hCG value after single embryo transfer fo2017-01-01T00:00:00Z20172025-04-26T18:49:06.953Z2019-03-27T02:41:37ZS-EPMC53968842842296410.1371/journal.pone.0172456