{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murray-Stewart T"],"funding":["Maryland Cigarette Restitution Fund","Samuel Waxman Cancer Research Foundation","NCI NIH HHS","National Institutes of Health","National Institute of Biomedical Imaging and Bioengineering"],"pagination":["e0175917"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5396973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, bis(ethyl)norspermine (BENSpm), that could simultaneously target polyamine metabolism while delivering therapeutic nucleic acids. In the current study, we describe the synthesis and evaluation of self-immolative nanocarriers derived from the second-generation polyamine analogue PG-11047. Polyamines are absolutely essential for proliferation and their metabolism is frequently dysregulated in cancer. Through its effects on polyamine metabolism, PG-11047 effectively inhibits tumor growth in cancer cell lines of multiple origins as well as in human "],"journal":["PloS one"],"pubmed_title":["Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047."],"pmcid":["PMC5396973"],"funding_grant_id":["EB015216","S30-CA006973","R01-CA204345","EB014570","R01 CA204345"],"pubmed_authors":["Oupicky D","Xie Y","Ferrari E","Marton LJ","Murray-Stewart T","Yu F","Casero RA"],"additional_accession":[]},"is_claimable":false,"name":"Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.","description":"Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, bis(ethyl)norspermine (BENSpm), that could simultaneously target polyamine metabolism while delivering therapeutic nucleic acids. In the current study, we describe the synthesis and evaluation of self-immolative nanocarriers derived from the second-generation polyamine analogue PG-11047. Polyamines are absolutely essential for proliferation and their metabolism is frequently dysregulated in cancer. Through its effects on polyamine metabolism, PG-11047 effectively inhibits tumor growth in cancer cell lines of multiple origins as well as in human ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-05T19:37:44.244Z","creation":"2019-03-27T02:41:36Z"},"accession":"S-EPMC5396973","cross_references":{"pubmed":["28423064"],"doi":["10.1371/journal.pone.0175917"]}}