{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["46(2)"],"submitter":["Fallahzadeh-Abarghooei L"],"pubmed_abstract":["<h4>Background</h4>Sodium arsenite (NaAsO2) has potent cytotoxic activity in human cancer cells. Oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (<i>CAT</i>) and superoxide dismutase 2 (<i>SOD2</i>) in MCF-7 and Jurkat cells after exposure to NaAsO<sub>2</sub>.<h4>Methods</h4>Methylthiazol tetrazolium (MTT) viability assay was performed to evaluate cytotoxicity of NaAsO<sub>2</sub> in MCF-7 and Jurkat cells. For evaluating the expression levels of the <i>CAT</i> and <i>SOD2</i>, we used two concentrations of NaAsO<sub>2</sub> (5 and 15 μM), lower than the concentrations at which 50% of cell viability were lost. The cells were treated with co-treatment of NaAsO<s"],"journal":["Iranian journal of public health"],"pagination":["229-234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5402782"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Sodium Arsenite on the Expression of Antioxidant Genes (<i>SOD2</i> and <i>CAT</i>) in MCF-7 and Jurkat Cell Lines."],"pmcid":["PMC5402782"],"pubmed_authors":["Fallahzadeh-Abarghooei L","Saadat M","Samadaei-Ghadikolaie M","Saadat I"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Sodium Arsenite on the Expression of Antioxidant Genes (<i>SOD2</i> and <i>CAT</i>) in MCF-7 and Jurkat Cell Lines.","description":"<h4>Background</h4>Sodium arsenite (NaAsO2) has potent cytotoxic activity in human cancer cells. Oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (<i>CAT</i>) and superoxide dismutase 2 (<i>SOD2</i>) in MCF-7 and Jurkat cells after exposure to NaAsO<sub>2</sub>.<h4>Methods</h4>Methylthiazol tetrazolium (MTT) viability assay was performed to evaluate cytotoxicity of NaAsO<sub>2</sub> in MCF-7 and Jurkat cells. For evaluating the expression levels of the <i>CAT</i> and <i>SOD2</i>, we used two concentrations of NaAsO<sub>2</sub> (5 and 15 μM), lower than the concentrations at which 50% of cell viability were lost. The cells were treated with co-treatment of NaAsO<s","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-05T12:54:45.371Z","creation":"2019-06-06T17:21:57Z"},"accession":"S-EPMC5402782","cross_references":{"pubmed":["28451559"]}}