biostudies-literatureDerks EMStichting Volksbond RotterdamNIMH NIH HHSNational Institutes of Health360-368https://www.ebi.ac.uk/biostudies/studies/S-EPMC5403879biostudies-literatureUnknown47(3)Population divergence impacts the degree of population stratification in Genome Wide Association Studies. We aim to: (i) investigate type-I error rate as a function of population divergence (F_ST) in multi-ethnic (admixed) populations; (ii) evaluate the statistical power and effect size estimates; and (iii) investigate the impact of population stratification on the results of gene-based analyses. Quantitative phenotypes were simulated. Type-I error rate was investigated for Single Nucleotide Polymorphisms (SNPs) with varying levels of F_ST between the ancestral European and African populations. Type-II error rate was investigated for a SNP characterized by a high value of F_ST. In all tests, genomic MDS components were included to correct for population stratiBehavior geneticsThe Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.PMC5403879R01 MH101820MH101820MH090937R01 MH090937Gamazon ERDerks EMZwinderman AHfalseThe Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.Population divergence impacts the degree of population stratification in Genome Wide Association Studies. We aim to: (i) investigate type-I error rate as a function of population divergence (F_ST) in multi-ethnic (admixed) populations; (ii) evaluate the statistical power and effect size estimates; and (iii) investigate the impact of population stratification on the results of gene-based analyses. Quantitative phenotypes were simulated. Type-I error rate was investigated for Single Nucleotide Polymorphisms (SNPs) with varying levels of F_ST between the ancestral European and African populations. Type-II error rate was investigated for a SNP characterized by a high value of F_ST. In all tests, genomic MDS components were included to correct for population strati2017-01-01T00:00:00Z2017 May2025-04-05T12:54:58.891Z2019-06-06T17:22:08ZS-EPMC54038792818511110.1007/s10519-017-9837-3