biostudies-literatureUnknown18Gabrielsen CThe coagulase-negative bacterium <i>Staphylococcus condimenti</i> and closely related species are commonly isolated from or found in starter cultures of fermented sausage as well as fish and soy sauces, and have traditionally been considered nonpathogenic. Recently, however, a case of catheter-related bacteraemia caused by <i>S. condimenti</i> was reported. In the present study we identified and characterized a strain of <i>S. condimenti</i> isolated from a patient with a severe soft tissue infection, comparing it to <i>S. condimenti</i> and <i>S. carnosus</i> type strains in order to elucidate the virulence potential of the clinical strain. Genome comparison showed high degree of conservation between the clinical strain and the type strain used in food industry, as well as with <i>S. carnosus.</i> The genome of the clinical <i>S. condimenti</i> strain contains few horizontally transferred regions and 37 putative virulence genes, including genes with similarity to leucocidin and genes involved in immune evasion, proinflammatory and cytolytic activity. However, it remains to be tested whether these putative virulence genes are expressed and functional. Although uncommon, <i>S. condimenti</i> may cause severe infection in previously healthy persons.New microbes and new infections8-14https://www.ebi.ac.uk/biostudies/studies/S-EPMC5406524biostudies-literatureCharacterization of the virulence potential of <i>Staphylococcus condimenti</i> isolated from a patient with severe soft tissue infection.PMC5406524Bergh KKols NIAfset JEGabrielsen COye CfalseCharacterization of the virulence potential of <i>Staphylococcus condimenti</i> isolated from a patient with severe soft tissue infection.The coagulase-negative bacterium <i>Staphylococcus condimenti</i> and closely related species are commonly isolated from or found in starter cultures of fermented sausage as well as fish and soy sauces, and have traditionally been considered nonpathogenic. Recently, however, a case of catheter-related bacteraemia caused by <i>S. condimenti</i> was reported. In the present study we identified and characterized a strain of <i>S. condimenti</i> isolated from a patient with a severe soft tissue infection, comparing it to <i>S. condimenti</i> and <i>S. carnosus</i> type strains in order to elucidate the virulence potential of the clinical strain. Genome comparison showed high degree of conservation between the clinical strain and the type strain used in food industry, as well as with <i>S. carnosus.</i> The genome of the clinical <i>S. condimenti</i> strain contains few horizontally transferred regions and 37 putative virulence genes, including genes with similarity to leucocidin and genes involved in immune evasion, proinflammatory and cytolytic activity. However, it remains to be tested whether these putative virulence genes are expressed and functional. Although uncommon, <i>S. condimenti</i> may cause severe infection in previously healthy persons.2017-01-01T00:00:00Z2017 Jul2024-12-04T06:12:33.43Z2019-06-06T17:22:42ZS-EPMC54065242848004410.1016/j.nmni.2017.03.006