{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Teku GN"],"funding":["Vetenskapsrådet","Barncancerfonden"],"pubmed_abstract":["Primary immunodeficiencies (PIDs) form a large and heterogeneous group of mainly rare disorders that affect the immune system. T-cell deficiencies account for about one-tenth of PIDs, most of them being monogenic. Apart from genetic and clinical information, lots of other data are available for PID proteins and genes, including functions and interactions. Thus, it is possible to perform systems biology studies on the effects of PIDs on T-cell physiology and response. To achieve this, we reconstructed a T-cell network model based on literature mining and TPPIN, a previously published core T-cell network, and performed semi-quantitative dynamic network simulations on both normal and T-cell PID failure modes. The results for several loss-of-function PID simulations correspond to results of pr"],"journal":["PloS one"],"pagination":["e0176500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5407609"],"repository":["biostudies-literature"],"pubmed_title":["Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells."],"pmcid":["PMC5407609"],"pubmed_authors":["Teku GN","Vihinen M"],"additional_accession":[]},"is_claimable":false,"name":"Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells.","description":"Primary immunodeficiencies (PIDs) form a large and heterogeneous group of mainly rare disorders that affect the immune system. T-cell deficiencies account for about one-tenth of PIDs, most of them being monogenic. Apart from genetic and clinical information, lots of other data are available for PID proteins and genes, including functions and interactions. Thus, it is possible to perform systems biology studies on the effects of PIDs on T-cell physiology and response. To achieve this, we reconstructed a T-cell network model based on literature mining and TPPIN, a previously published core T-cell network, and performed semi-quantitative dynamic network simulations on both normal and T-cell PID failure modes. The results for several loss-of-function PID simulations correspond to results of pr","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-05T00:04:18.507Z","creation":"2019-03-26T22:49:43Z"},"accession":"S-EPMC5407609","cross_references":{"pubmed":["28448599"],"doi":["10.1371/journal.pone.0176500"]}}