{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang G"],"funding":["NIBIB NIH HHS","U.S. Department of Defense","Pennsylvania Department of Health","National Institutes of Health","NIAMS NIH HHS","National Institute of Biomedical Imaging and Bioengineering"],"pagination":["68-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5408748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35"],"pubmed_abstract":["Regeneration of injured tendon and ligament (T&L) remains a clinical challenge due to their poor intrinsic healing capacity. Tissue engineering provides a promising alternative treatment approach to facilitate T&L healing and regeneration. Successful tendon tissue engineering requires the use of three-dimensional (3D) biomimetic scaffolds that possess the physical and biochemical features of native tendon tissue. We report here the development and characterization of a novel composite scaffold fabricated by co-electrospinning of poly-ε-caprolactone (PCL) and methacrylated gelatin (mGLT). We found that photocrosslinking retained mGLT, resulted in a uniform distribution of mGLT throughout the depth of scaffold and also preserved scaffold mechanical strength. Moreover, photocrosslinking was a"],"journal":["Acta biomaterialia"],"pubmed_title":["Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering."],"pmcid":["PMC5408748"],"funding_grant_id":["W81XWH-08-2-0032","W81XWH-15-1-0104","SAP 4100050913","R01 AR062947","T32EB001026","5R01 AR062947","W81XWH-11-2-0143","T32 EB001026","W81XWH-14-2-0003"],"pubmed_authors":["Yang G","Rothrauff BB","Yu S","Tuan RS","Lin H"],"additional_accession":[]},"is_claimable":false,"name":"Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering.","description":"Regeneration of injured tendon and ligament (T&L) remains a clinical challenge due to their poor intrinsic healing capacity. Tissue engineering provides a promising alternative treatment approach to facilitate T&L healing and regeneration. Successful tendon tissue engineering requires the use of three-dimensional (3D) biomimetic scaffolds that possess the physical and biochemical features of native tendon tissue. We report here the development and characterization of a novel composite scaffold fabricated by co-electrospinning of poly-ε-caprolactone (PCL) and methacrylated gelatin (mGLT). We found that photocrosslinking retained mGLT, resulted in a uniform distribution of mGLT throughout the depth of scaffold and also preserved scaffold mechanical strength. Moreover, photocrosslinking was a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-04T13:14:30.497Z","creation":"2019-03-27T02:42:15Z"},"accession":"S-EPMC5408748","cross_references":{"pubmed":["26945631"],"doi":["10.1016/j.actbio.2016.03.004"]}}